Early Diagnosis of Neonatal Sepsis
In an article presented by the Journal of Pediatric Infectious Diseases, the abstract of the article states that sepsis is one of the most significant contributors to mortality and morbidity in the neonatal population. The need to find specific biomarkers that provide meaningful information about the diagnosis of sepsis in neonatals is ongoing. The article calls out the study aimed to investigate the utility of N-terminal pro b-type natriuretic peptide (NT-proBNP) as a diagnostic biomarker in newborn infants with late-onset sepsis. This marker is associated with blood volume and pressure and with the work that the heart must do in pumping blood throughout the body. The marker is primarily used to help detect, diagnose and evaluate the severity of heart failure. BNP is a hormone produced by the heart. Levels go up when heart failure develops or gets worse, and levels go down when the heart failure is stable. The marker of cardiac dysfunction is associated with sepsis in preterm neonates.
The increased levels of B-type natriuretic peptide (BNP) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) are related with the dysfunction of a cardiovascular system and systemic inflammation.
In the study that was done, it included 87 patients diagnosed with sepsis and 35 controlled patients. The median NT-proBNP were higher in septic patients showing a significant correlation in measuring white blood cell count, serum C-reactive proteins (CRP), plasma interleukin and whole blood levels.
In conclusion, plasma NT-proBNP levels were higher in septic neonates.
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